Contraindicated (1)pentobarbital decreases amounts of vandetanib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration with strong CYP3A4 inducers; these medications minimize exposure to vandetanib by around 40%.pentobarbital will lower the level or outcome of fosaprepitant by influencing hepatic
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